Linked Life Data

2445656

Source:http://linkedlifedata.com/resource/pubmed/id/2445656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-12-31
pubmed:abstractText
Five hybridoma cell lines were established that secrete monoclonal antibodies (MAbs) directed against rat plasma low molecular weight plasma kininogen. Two of the secreted antibodies were of the IgG1k isotype. The remaining three were of the IgG1 lambda, IgG2ak and IgMk isotypes, respectively. The dissociation constants (Kd) of these MAbs ranged from 0.58 X 10(-9) M to 5.4 X 10(-9) M. At least two distinct epitopes on the rat plasma kininogen were recognized by these MAbs. Further characterization of the MAbs showed that four MAbs cross-reacted strongly with kininogen from the Murphy-Sturm lymphosarcoma (MSLS) tumor while one of the MAbs cross-reacted weakly with MSLS tumor kininogen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0272-457X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
521-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Production and characterization of monoclonal antibodies to rat plasma kininogen.
pubmed:affiliation
Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.