Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1988-1-11
pubmed:databankReference
pubmed:abstractText
We determined the nucleotide sequence of two HTF islands that were selected at random from mouse chromosomal DNA. Both were non-methylated, G + C rich, and contained CpG at close to the expected frequency. When used as probes, the two islands detected multiple transcripts in RNA from several mouse tissues. Cloned cDNAs for the major transcripts of one island (HTF9) were isolated and used to construct a transcriptional map. We found that HTF9 contains the origin of a pair of divergent transcripts that are probably messenger RNAs. The bidirectional promoter is different from those previously observed as the major transcription start sites for each orientation are coincident on opposite strands of the DNA. The results support the view that HTF islands often mark genes, and they suggest that bidirectional transcription may be a common feature of island promoters.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-2408272, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-2423876, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-2866091, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-2880336, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-2981636, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3016554, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3018531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3023846, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3025660, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3455894, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3595568, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-3779834, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6088070, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6092050, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6154876, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6188105, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6204550, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6235151, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6302681, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6326107, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6329026, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6330683, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-6587321, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-7063411, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-7105182, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-7226224, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445562-837449
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2773-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2445562-Amino Acid Sequence, pubmed-meshheading:2445562-Animals, pubmed-meshheading:2445562-Base Sequence, pubmed-meshheading:2445562-Cloning, Molecular, pubmed-meshheading:2445562-Cytidine Monophosphate, pubmed-meshheading:2445562-Cytosine Nucleotides, pubmed-meshheading:2445562-DNA, pubmed-meshheading:2445562-DNA Restriction Enzymes, pubmed-meshheading:2445562-Deoxyribonuclease HpaII, pubmed-meshheading:2445562-Dinucleoside Phosphates, pubmed-meshheading:2445562-Guanosine, pubmed-meshheading:2445562-Mice, pubmed-meshheading:2445562-Molecular Sequence Data, pubmed-meshheading:2445562-Nucleic Acid Hybridization, pubmed-meshheading:2445562-Nucleotide Mapping, pubmed-meshheading:2445562-Promoter Regions, Genetic, pubmed-meshheading:2445562-RNA, pubmed-meshheading:2445562-Transcription, Genetic
pubmed:year
1987
pubmed:articleTitle
Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse.
pubmed:affiliation
MRC Mammalian Genome Unit, Edinburgh, Scotland, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't