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rdf:type |
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lifeskim:mentions |
umls-concept:C0001480,
umls-concept:C0006945,
umls-concept:C0009647,
umls-concept:C0017725,
umls-concept:C0030274,
umls-concept:C0205101,
umls-concept:C0205156,
umls-concept:C0332157,
umls-concept:C0596233,
umls-concept:C1176299,
umls-concept:C1998548
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pubmed:issue |
2
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pubmed:dateCreated |
1987-12-24
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pubmed:abstractText |
1 Exposure to ATP (2-200 microM) resulted in a prominent peak of 45Ca efflux, when beta-cell-rich pancreatic islets from ob/ob-mice were perifused with a Ca2+-deficient medium. ADP and the stable alpha/beta-methylene analogues of ATP and ADP also had stimulatory effects. 2 The nucleotide initiation of 45Ca efflux mimicked that obtained with carbachol both in requiring previous exposure to glucose and in being more pronounced after replacing extracellular Na+ by K+. 3 It was possible to induce repeated peaks of stimulated 45Ca efflux, when the exposure to ATP was interrupted with intervals of perifusion with glucose-containing media. 4 The observations are consistent with the existence of P2-purinoceptors in islets, suggesting that these receptors mediate a similar mobilization of calcium as noted when activating polyphosphoinositide breakdown with carbachol. In view of the high contents of ATP and ADP in the beta-cell secretory granules, activation of P2-purinoceptors should be considered as a possible mechanism for amplification of the initial insulin secretory response.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-13974649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-169123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-176322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-2992453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-2992800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-2996968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3004360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3007462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3010944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3086908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3300191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-339959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-3900411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-393523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-4030763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-4192895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-4353011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-4369334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-5323924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6092036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6097328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6162455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6171640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6309153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6344863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-6436050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445404-7035188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2445404-Adenine Nucleotides,
pubmed-meshheading:2445404-Adenosine Diphosphate,
pubmed-meshheading:2445404-Adenosine Triphosphate,
pubmed-meshheading:2445404-Animals,
pubmed-meshheading:2445404-Calcium Radioisotopes,
pubmed-meshheading:2445404-Carbachol,
pubmed-meshheading:2445404-Glucose,
pubmed-meshheading:2445404-Ion Channels,
pubmed-meshheading:2445404-Islets of Langerhans,
pubmed-meshheading:2445404-Mice,
pubmed-meshheading:2445404-Mice, Inbred Strains,
pubmed-meshheading:2445404-Receptors, Muscarinic
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pubmed:year |
1987
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pubmed:articleTitle |
External ATP mimics carbachol in initiating calcium mobilization from pancreatic beta-cells conditioned by previous exposure to glucose.
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pubmed:affiliation |
Department of Medical Cell Biology, University of Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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