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rdf:type |
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lifeskim:mentions |
umls-concept:C0001347,
umls-concept:C0015980,
umls-concept:C0021760,
umls-concept:C0205164,
umls-concept:C0227525,
umls-concept:C0237876,
umls-concept:C0332307,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1521761,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2003939,
umls-concept:C2911692
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pubmed:issue |
20
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pubmed:dateCreated |
1987-11-25
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pubmed:abstractText |
One of the oldest and most preserved of the homeostatic responses of the body to injury is the acute phase protein response associated with inflammation. The liver responds to hormone-like mediators by the increased synthesis of a series of plasma proteins called acute phase reactants. In these studies, we examined the relationship of hepatocyte-stimulating factor derived from peripheral blood monocytes to interferon beta 2 (IFN-beta 2), which has been cloned. Antibodies raised against fibroblast-derived IFN-beta having neutralizing activity against both IFN-beta 1 and -beta 2 inhibited the major hepatocyte-stimulating activity derived from monocytes. Fibroblast-derived mediator elicited the identical stimulated response in human HepG2 cells and primary rat hepatocytes as the monocyte cytokine. Finally, recombinant-derived human B-cell stimulatory factor type 2 (IFN-beta 2) from Escherichia coli induced the synthesis of all major acute phase proteins studied in human hepatoma HepG2 and primary rat hepatocyte cultures. These data demonstrate that monocyte-derived hepatocyte-stimulating factor and IFN-beta 2 share immunological and functional identity and that IFN-beta 2, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-19869788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-19871070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2411843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2418029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2429991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2434417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2439511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2579159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2871942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-2997929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3017995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3023045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3029503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3088147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3298514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3491322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3492676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3492764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3493322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3494192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3496098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3538015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3545852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3758081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3876934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-3883360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6083778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6159547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6164058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6184374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6202694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6369481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-6807179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-7046585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-7327696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2444978-97380
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7251-5
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:2444978-Acute-Phase Proteins,
pubmed-meshheading:2444978-Animals,
pubmed-meshheading:2444978-Antibodies,
pubmed-meshheading:2444978-Carcinoma, Hepatocellular,
pubmed-meshheading:2444978-Fibroblasts,
pubmed-meshheading:2444978-Gene Expression Regulation,
pubmed-meshheading:2444978-Humans,
pubmed-meshheading:2444978-Inflammation,
pubmed-meshheading:2444978-Interferon Type I,
pubmed-meshheading:2444978-Interleukin-6,
pubmed-meshheading:2444978-Leukocytes, Mononuclear,
pubmed-meshheading:2444978-Liver,
pubmed-meshheading:2444978-Liver Neoplasms,
pubmed-meshheading:2444978-Liver Neoplasms, Experimental,
pubmed-meshheading:2444978-Neoplasm Proteins,
pubmed-meshheading:2444978-Proteins,
pubmed-meshheading:2444978-Rats,
pubmed-meshheading:2444978-Recombinant Proteins,
pubmed-meshheading:2444978-Tumor Cells, Cultured
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pubmed:year |
1987
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pubmed:articleTitle |
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
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