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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-11-24
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pubmed:abstractText |
In mouse mammary epithelial cells in primary culture, mechanical stimulation of a cell induced in other cells within the same colony a short depolarization of less than 15 mV with a duration of 1-8 s and a subsequent, prominent hyperpolarization of 6 mV lasting 10-40 s. Epidermal growth factor induces a spontaneous hyperpolarizing response in cultured mammary cells, and in cells treated with EGF mechanical stimulation produced a greater hyperpolarization, while the amplitude of the depolarizing response was not affected. The amplitude of the mechanically induced hyperpolarization was markedly reduced by quinine and tetraethylammonium, blockers of the Ca2+ -dependent K+ channel. The results suggest that the Ca2+ -dependent K+ channel was involved in the hyperpolarization.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Quinine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium Compounds
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
223
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2444460-Animals,
pubmed-meshheading:2444460-Calcium,
pubmed-meshheading:2444460-Cells, Cultured,
pubmed-meshheading:2444460-Electrophysiology,
pubmed-meshheading:2444460-Epithelial Cells,
pubmed-meshheading:2444460-Epithelium,
pubmed-meshheading:2444460-Insulin,
pubmed-meshheading:2444460-Ion Channels,
pubmed-meshheading:2444460-Mammary Glands, Animal,
pubmed-meshheading:2444460-Membrane Potentials,
pubmed-meshheading:2444460-Mice,
pubmed-meshheading:2444460-Quinine,
pubmed-meshheading:2444460-Stress, Mechanical,
pubmed-meshheading:2444460-Tetraethylammonium Compounds
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pubmed:year |
1987
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pubmed:articleTitle |
Mechanically induced electrical responses in murine mammary epithelial cells in primary culture.
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pubmed:affiliation |
Laboratory of Cell Biology and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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