Linked Life Data

2443934

Source:http://linkedlifedata.com/resource/pubmed/id/2443934

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-10-29
pubmed:abstractText
The cerebral content of the biogenic amines, dopamine (DA), norepinephrine (NE), and serotonin (5-HT) and their catabolites 30 min after CRF or saline injections was determined using HPLC with electrochemical detection. Injection of CRF (1.0 micrograms) into the lateral ventricles (ICV) of mice produced a behavioral activation in which their motor movements appeared as bursts of activity followed by periods of immobility. CRF administration (ICV or SC) did not alter the concentrations of DA, NE, tryptophan, 5-HT, or 5-hydroxyindoleacetic acid (5-HIAA) in any brain region measured. ICV CRF increased the concentrations of dihydroxyphenylacetic acid (DOPAC), the major catabolite of DA, and of 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG), the major catabolite of NE, in several brain regions. DOPAC:DA ratios were consistently increased in prefrontal cortex, septum, hypothalamus, and brain stem relative to animals injected with saline. MHPG:NE ratios were also increased in the prefrontal cortex and hypothalamus, with a marginal effect (p = 0.06) in brain stem. SC CRF significantly increased DOPAC:DA in prefrontal cortex, and MHPG:NE in prefrontal cortex, hypothalamus and brain stem. Pretreatment with naloxone did not prevent any of the neurochemical responses to ICV CRF, but naloxone alone increased DOPAC:DA in medial profrontal cortex, and decreased MHPG:NE in nucleus accumbens in CRF-injected mice. These results suggest that administration of CRF either centrally or peripherally induces an activation of both dopaminergic and noradrenergic systems in several regions of mouse brain.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
685-91
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:2443934-3,4-Dihydroxyphenylacetic Acid, pubmed-meshheading:2443934-Animals, pubmed-meshheading:2443934-Behavior, Animal, pubmed-meshheading:2443934-Biogenic Amines, pubmed-meshheading:2443934-Brain, pubmed-meshheading:2443934-Catecholamines, pubmed-meshheading:2443934-Chromatography, High Pressure Liquid, pubmed-meshheading:2443934-Corticotropin-Releasing Hormone, pubmed-meshheading:2443934-Dopamine, pubmed-meshheading:2443934-Hydroxyindoleacetic Acid, pubmed-meshheading:2443934-Injections, Intraventricular, pubmed-meshheading:2443934-Male, pubmed-meshheading:2443934-Methoxyhydroxyphenylglycol, pubmed-meshheading:2443934-Mice, pubmed-meshheading:2443934-Naloxone, pubmed-meshheading:2443934-Norepinephrine, pubmed-meshheading:2443934-Serotonin, pubmed-meshheading:2443934-Stress, Physiological, pubmed-meshheading:2443934-Tissue Distribution, pubmed-meshheading:2443934-Tryptophan
pubmed:year
1987
pubmed:articleTitle
Corticotropin-releasing factor administration elicits a stress-like activation of cerebral catecholaminergic systems.
pubmed:affiliation
Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.