Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-4-26
pubmed:abstractText
Proteoglycans were extracted from normal human articular cartilage of various ages with 4M-guanidinium chloride and were purified and characterized by using preformed linear CsCl density gradients. With advancing age, there was a decrease in high-density proteoglycans of low protein/uronic acid weight ratio and an increase in the proportion of lower-density proteoglycans, richer in keratan sulphate and protein. Proteoglycans of each age were also shown to disaggregate in 4M-guanidinium chloride and at low pH and to reaggregate in the presence of hyaluronic acid and/or low-density fractions. Osteoarthrotic-cartilage extracts had an increased content of higher-density proteoglycans compared with normal cartilage of the same age, and results also suggested that these were not mechanical or enzymic degradation products, but were possibly proteoglycans of an immature nature.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-123161, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-126087, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-13276341, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-134698, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-13704549, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-13726462, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-13759520, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-13971270, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-14099644, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-14107185, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4237578, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4250553, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4255496, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4263036, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4263642, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4268548, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4269254, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4277351, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4277352, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4277353, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4277512, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-4278603, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-5102885, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-5506265, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-576611, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-5783840, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-5787254, http://linkedlifedata.com/resource/pubmed/commentcorrection/24438-5840534
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Isolation of proteoglycans from human articular cartilage.
pubmed:publicationType
Journal Article