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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1987-11-16
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pubmed:abstractText |
1. Voltage-clamp Na+ currents (INa) were studied in rat soleus slow-twitch muscle fibres at about 18 degrees C using the loose-patch-clamp technique. The maximum inward current density was produced by depolarizations to about -19 mV. 2. Fast inactivation was studied utilizing 20 ms conditioning potentials. INa was reduced by 50% with conditioning potentials to about -70 mV. 3. Changes in the conditioning membrane potential produced slow changes in the peak INa due to a slow inactivation process. INa was reduced by 50% at about -86 mV due to slow inactivation. 4. The mean maximum inward INa when slow inactivation was fully removed was 6.83 mA cm-2. 5. Due to the slow inactivation process, slow-twitch fibres were less susceptible to reduction in INa than fast-twitch fibres.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-1082773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-1249849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-2443649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-2578630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4020687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4148752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4261555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4778131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-4904270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-5300936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6096482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6100456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6257898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6294591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6296672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6308223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6310086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6319538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6323705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-671323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-6913470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-7020843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-7205665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-7205672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-874895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2443650-903895
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
383
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-48
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1987
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pubmed:articleTitle |
Comparison between slow sodium channel inactivation in rat slow- and fast-twitch muscle.
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pubmed:affiliation |
Department of Neurology, Cleveland Veterans Administration Hospital, OH 44106.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
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