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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1987-11-6
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pubmed:abstractText |
Ninety ovarian carcinoma patients failing primary intravenous (IV) combination chemotherapy were treated with cisplatin-based combination intraperitoneal therapy. Sixty-five patients had residual disease greater than 2 cm at the start of intraperitoneal therapy. Their median survival was 8 months. Twenty-five patients had disease less than 2 cm; their median survival was greater than 49 months, and the survival curve has an apparent plateau at 69%, with no relapses having occurred after 32 months. The median survival for all 90 patients was 15 months. The median duration of follow-up for all patients was 37 months. These results confirm the critical role of tumor bulk in determining the effectiveness of intraperitoneal therapy, and suggest a role for intraperitoneal salvage treatment in patients with small-volume disease.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
0732-183X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1607-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2443622-Actuarial Analysis,
pubmed-meshheading:2443622-Adult,
pubmed-meshheading:2443622-Aged,
pubmed-meshheading:2443622-Aged, 80 and over,
pubmed-meshheading:2443622-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2443622-Bleomycin,
pubmed-meshheading:2443622-Cisplatin,
pubmed-meshheading:2443622-Cytarabine,
pubmed-meshheading:2443622-Doxorubicin,
pubmed-meshheading:2443622-Drug Evaluation,
pubmed-meshheading:2443622-Female,
pubmed-meshheading:2443622-Follow-Up Studies,
pubmed-meshheading:2443622-Humans,
pubmed-meshheading:2443622-Injections, Intraperitoneal,
pubmed-meshheading:2443622-Middle Aged,
pubmed-meshheading:2443622-Ovarian Neoplasms,
pubmed-meshheading:2443622-Risk
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pubmed:year |
1987
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pubmed:articleTitle |
Long-term survival of advanced refractory ovarian carcinoma patients with small-volume disease treated with intraperitoneal chemotherapy.
|
pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla 92093.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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