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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1987-11-12
|
| pubmed:abstractText |
We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decreases in the total peripheral T cells, TH cells, and TH/TS ratio as well as elevated alpha IFN serum levels were found in the MHS group in comparison with normal controls. Although no difference in the prevalence of either immune derangements or elevated serum IFN was observed between HTLVIII/LAV-seropositive and HTLVIII/LAV-seronegative MHS, the decreases in total T cells, TH cells, and TH/TS ratios were significantly greater in the seropositive MHS. These results indicate that (a) immune impairments and IFN system activation occur commonly in homosexuals, precede their exposure to HTLVIII/LAV, and probably reflect this group's increased risk for AIDS and (b) HTLVIII/LAV infection of MHS aggravates further their preexisting immune impairments.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANTIBODIES,
http://linkedlifedata.com/resource/pubmed/keyword/Acquired Immunodeficiency Syndrome,
http://linkedlifedata.com/resource/pubmed/keyword/Asia,
http://linkedlifedata.com/resource/pubmed/keyword/Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Control Groups,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hematologic Tests,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Homosexuals,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY,
http://linkedlifedata.com/resource/pubmed/keyword/ISRAEL,
http://linkedlifedata.com/resource/pubmed/keyword/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Immunological Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/Mediterranean Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Multiple Partners,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Population At Risk,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Sexual Partners,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Western Asia
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0271-9142
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
376-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:otherAbstract |
PIP: In 1983, researchers studied 288 asymptomatic Israeli male homosexuals (mean age, 30.8 years) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). These men reported an average of 11.8 years of homosexual experience and an average of 42 partners/year. 26% of the participants had mild inguinal lymphoadenopathy in the beginning of the study and 8 of the 26% later developed generalized lymphoadenopathy. Further, HTLVIII infection progressed to AIDS in 3 of the 288 men during follow-up observations. Laboratory personnel tested each participant's blood for HTLVI and HTLVIII antibodies by using the ELISA technique and positive results were confirmed by immunoblotting, titration, and specific competition with either HTLVI or HTLVIII. The seropositivity prevalence for HTLVI, HTLVIII, or both was 1.4, 8.3, and 0% respectively. No antibodies to either virus were present in the control subjects. Researchers noted significant increases in the level of serum IFN (2SD) in 50% of both seronegative and seropositive homosexuals, when compared with the control group. Significantly more lymphoid population impairment existed in the HTLVIII seropositive homosexuals than in the HTLVIII seronegative homosexuals, but more lymphoid population impairment was found among the HTLVIII seronegative homosexuals than the controls. Therefore, this study provides evidence that such abnormalities in seronegative individuals are present prior to any exposure to the HTLVIII virus. Thus, infection with the virus probably aggravates the preexisting immune impairments, leading eventually to the development of AIDS.
|
| pubmed:meshHeading |
pubmed-meshheading:2443528-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2443528-Adult,
pubmed-meshheading:2443528-Antibodies, Viral,
pubmed-meshheading:2443528-Deltaretrovirus,
pubmed-meshheading:2443528-HIV,
pubmed-meshheading:2443528-HIV Antibodies,
pubmed-meshheading:2443528-Homosexuality,
pubmed-meshheading:2443528-Humans,
pubmed-meshheading:2443528-Interferons,
pubmed-meshheading:2443528-Israel,
pubmed-meshheading:2443528-Lymphocytes,
pubmed-meshheading:2443528-Male,
pubmed-meshheading:2443528-Risk
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Immune impairments and antibodies to HTLVIII/LAV in asymptomatic male homosexuals in Israel: relevance to the risk of acquired immune deficiency syndrome (AIDS).
|
| pubmed:affiliation |
Ruth Ben Ari Institute of Clinical Immunology, Kaplan Hospital, Rehovot, Israel.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|