| pubmed-article:2443252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2443252 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2443252 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2443252 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:2443252 | lifeskim:mentions | umls-concept:C0019627 | lld:lifeskim |
| pubmed-article:2443252 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:2443252 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2443252 | pubmed:dateCreated | 1987-11-16 | lld:pubmed |
| pubmed-article:2443252 | pubmed:abstractText | We have studied the relationship between major histocompatibility complex (MHC)-restricted antigen recognition and alloreactivity by examining T cell receptor (TCR) alpha and beta gene expression in cytochrome c-specific, Ek alpha:Ek beta (Ek)-restricted helper T cell clones derived from B10.A mice. The clones could be segregated on the basis of four distinct alloreactivity patterns. Clones cross-reactive for three different allogeneic la molecules (As alpha:As beta [As], Ab alpha:Ab beta [Ab], Ek alpha: Eb beta [Eb]) expressed the same V alpha and V beta gene segments, generating the distinct alloreactive specificities via unique V alpha-J alpha and V beta-D beta-J beta joining events. Ek alpha:Es beta (Es)-alloreactive B10.A clones expressed the same V alpha, J alpha, and V beta segments as an Es-restricted, Ek-alloreactive, cytochrome c-specific, H-2-congenic B10.S(9R) clone. This homology between TCRs mediating allorecognition of la molecules and recognition of the same la molecules as restriction elements associated with nominal antigen suggests that MHC-restricted recognition and allorecognition represent differences in the affinity of the TCR-MHC molecule interaction. | lld:pubmed |
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| pubmed-article:2443252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2443252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2443252 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2443252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2443252 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2443252 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2443252 | pubmed:author | pubmed-author:FinkP JPJ | lld:pubmed |
| pubmed-article:2443252 | pubmed:author | pubmed-author:HedrickS MSM | lld:pubmed |
| pubmed-article:2443252 | pubmed:author | pubmed-author:McElligottD... | lld:pubmed |
| pubmed-article:2443252 | pubmed:author | pubmed-author:MatisL ALA | lld:pubmed |
| pubmed-article:2443252 | pubmed:author | pubmed-author:SorgerS BSB | lld:pubmed |
| pubmed-article:2443252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2443252 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:2443252 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:2443252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2443252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2443252 | pubmed:pagination | 59-69 | lld:pubmed |
| pubmed-article:2443252 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2443252 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2443252 | pubmed:articleTitle | The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. | lld:pubmed |
| pubmed-article:2443252 | pubmed:affiliation | Molecular Immunology Laboratory, Food and Drug Administration, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:2443252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2443252 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2443252 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2443252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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