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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1987-11-16
|
| pubmed:abstractText |
We have studied the relationship between major histocompatibility complex (MHC)-restricted antigen recognition and alloreactivity by examining T cell receptor (TCR) alpha and beta gene expression in cytochrome c-specific, Ek alpha:Ek beta (Ek)-restricted helper T cell clones derived from B10.A mice. The clones could be segregated on the basis of four distinct alloreactivity patterns. Clones cross-reactive for three different allogeneic la molecules (As alpha:As beta [As], Ab alpha:Ab beta [Ab], Ek alpha: Eb beta [Eb]) expressed the same V alpha and V beta gene segments, generating the distinct alloreactive specificities via unique V alpha-J alpha and V beta-D beta-J beta joining events. Ek alpha:Es beta (Es)-alloreactive B10.A clones expressed the same V alpha, J alpha, and V beta segments as an Es-restricted, Ek-alloreactive, cytochrome c-specific, H-2-congenic B10.S(9R) clone. This homology between TCRs mediating allorecognition of la molecules and recognition of the same la molecules as restriction elements associated with nominal antigen suggests that MHC-restricted recognition and allorecognition represent differences in the affinity of the TCR-MHC molecule interaction.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Recombinant,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-69
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2443252-Animals,
pubmed-meshheading:2443252-Clone Cells,
pubmed-meshheading:2443252-Columbidae,
pubmed-meshheading:2443252-Cytochrome c Group,
pubmed-meshheading:2443252-DNA,
pubmed-meshheading:2443252-DNA, Recombinant,
pubmed-meshheading:2443252-Epitopes,
pubmed-meshheading:2443252-Female,
pubmed-meshheading:2443252-Genes, Immunoglobulin,
pubmed-meshheading:2443252-Histocompatibility Antigens Class II,
pubmed-meshheading:2443252-Isoantigens,
pubmed-meshheading:2443252-Lymphocyte Activation,
pubmed-meshheading:2443252-Major Histocompatibility Complex,
pubmed-meshheading:2443252-Male,
pubmed-meshheading:2443252-Mice,
pubmed-meshheading:2443252-Moths,
pubmed-meshheading:2443252-Nucleic Acid Hybridization,
pubmed-meshheading:2443252-Receptors, Antigen, T-Cell,
pubmed-meshheading:2443252-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones.
|
| pubmed:affiliation |
Molecular Immunology Laboratory, Food and Drug Administration, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|