Linked Life Data

2443030

Source:http://linkedlifedata.com/resource/pubmed/id/2443030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-10-19
pubmed:abstractText
Thirty-two rats had truncal vagotomy either with or without pyloroplasty. After 2 or 4 weeks, respectively, the pancreas was excised and weighed. Measurements of amylase, trypsin, lipase, total protein, and DNA were obtained from the homogenated pancreatic tissue. Isolated pancreatic lobules were incubated with and without ceruletide (5 X 10(-10) g/ml) during a 60 minute period. Amylase values were determined four times in the incubation medium. Morphometry was performed by light microscopy analysis. There was a significant increase in pancreatic weight, DNA content, and trypsin concentration 2 weeks after vagotomy with and without pyloroplasty. These changes were accelerated after 4 weeks. DNA, amylase, and total protein concentrations were unchanged. Lipase concentration decreased 2 weeks after vagotomy and pyloroplasty, whereas at 4 weeks, it decreased in both experimental groups. The in vitro incubation study revealed a significantly decreased amylase discharge under basal conditions, whereas the stimulated amylase discharge was unchanged in both experimental groups compared with the control group. Morphometry did not detect differences in exocrine cellular size. We conclude that vagotomy in rats induces pancreatic hyperplasia, enzyme dissociation, and decreased basal amylase discharge in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9610
pubmed:author
pubmed:issnType
Print
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
300-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Pancreatic trophism after truncal vagotomy in rats.
pubmed:publicationType
Journal Article