Linked Life Data

2442717

Source:http://linkedlifedata.com/resource/pubmed/id/2442717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-10-16
pubmed:abstractText
(1). The effects of benzene and several of its derivatives on sodium currents in the voltage-clamped squid giant axon have been studied. Substances tested were benzene, aniline, benzyl alcohol, propiophenone, 4-amino-propiophenone, methyl benzoate, ethyl benzoate, and 4-amino ethyl benzoate (benzocaine). (2.) All substances tested reduced the sodium current in both intact axons and axons internally perfused with CsF. (3.) There were four major actions of benzene on the sodium current: (a) an increase in the resting level of inactivation, (b) an increase in the depolarization required to produce the maximum current, (c) a decrease in the maximum sodium conductance, and (d) an increase in the rate of inactivation. (4.) 4-amino ethyl benzoate (benzocaine) had actions on the sodium current which were very similar to those of benzene with the exception that the rate of inactivation was scarcely affected and, at comparable shifts, the slope of the steady state inactivation curve was slightly smaller. (5.) The results obtained with the substances structurally intermediate between benzene and 4-amino ethyl benzoate allow some conclusions to be drawn as to the role of each functional group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
409
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
589-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Local anaesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't