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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1987-10-7
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pubmed:databankReference |
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pubmed:abstractText |
The transformer (tra) gene regulates female somatic sexual differentiation and has no known function in males. It gives rise to two sizes of RNA, one non-sex-specific and one female-specific. These two RNAs are shown to be present throughout the life cycle, and related by the use of alternative first intron splice acceptor sites. The non-sex-specific RNA has a 73 base first intron, while that in the female-specific RNA is 248 bases. The non-sex-specific RNA has no long open reading frame, while the female-specific RNA has a single long open reading frame beginning at the first AUG. Substitution of a heat shock promoter for the tra promoter still leads to female-specific differentiation of otherwise tra-females. We suggest a mechanism by which Sex-lethal controls itself and tra.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-47
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2441872-Animals,
pubmed-meshheading:2441872-Base Sequence,
pubmed-meshheading:2441872-DNA,
pubmed-meshheading:2441872-DNA, Recombinant,
pubmed-meshheading:2441872-Drosophila melanogaster,
pubmed-meshheading:2441872-Endonucleases,
pubmed-meshheading:2441872-Female,
pubmed-meshheading:2441872-Genes, Lethal,
pubmed-meshheading:2441872-Heat-Shock Proteins,
pubmed-meshheading:2441872-Male,
pubmed-meshheading:2441872-Nucleic Acid Hybridization,
pubmed-meshheading:2441872-Poly A,
pubmed-meshheading:2441872-Promoter Regions, Genetic,
pubmed-meshheading:2441872-RNA,
pubmed-meshheading:2441872-RNA, Messenger,
pubmed-meshheading:2441872-RNA Splicing,
pubmed-meshheading:2441872-Sex Differentiation,
pubmed-meshheading:2441872-Single-Strand Specific DNA and RNA Endonucleases,
pubmed-meshheading:2441872-Transcription, Genetic
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pubmed:year |
1987
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pubmed:articleTitle |
Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
