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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0013936,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0017471,
umls-concept:C0024554,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0443199,
umls-concept:C2911684
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pubmed:issue |
16
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pubmed:dateCreated |
1987-9-18
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pubmed:abstractText |
Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-1055416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-1061118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-11539049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-162962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-17247933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2416459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2416462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2426103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2429320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2436220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2873572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2878803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2879244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2879245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2879247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-2892757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-3007994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-3019676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-3453105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-3726554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4000278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4022010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4043522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4058581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4075393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-476239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-5166852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-590624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6198133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6323992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6327065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6330741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6598339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6690448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6709062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6722870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441396-6893015
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5813-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2441396-Alleles,
pubmed-meshheading:2441396-Animals,
pubmed-meshheading:2441396-Gene Expression Regulation,
pubmed-meshheading:2441396-Genes, Homeobox,
pubmed-meshheading:2441396-Male,
pubmed-meshheading:2441396-Mice,
pubmed-meshheading:2441396-Mutation,
pubmed-meshheading:2441396-Nucleic Acid Hybridization,
pubmed-meshheading:2441396-Poly A,
pubmed-meshheading:2441396-RNA,
pubmed-meshheading:2441396-RNA, Messenger,
pubmed-meshheading:2441396-Testis,
pubmed-meshheading:2441396-Transcription, Genetic
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pubmed:year |
1987
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pubmed:articleTitle |
Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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