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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1987-9-18
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pubmed:databankReference |
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pubmed:abstractText |
Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous system. We have isolated a copy of an alternatively spliced PLP gene transcript from a mouse brain cDNA library that was screened for PLP-related sequences. The encoded 241-amino acid protein differs from PLP by an internal deletion of 35-amino acid residues (116-150) from the major hydrophilic domain. This PLP variant is identical with the DM-20 protein of myelin, previously described as a brain-specific myelin component and known to be related to PLP. We determined the corresponding nucleotide sequence of the rat PLP gene and found that DM-20 mRNA results when a second 5' splice site, located 105 nucleotides within the third exon of the primary PLP transcript, is utilized in precursor mRNA (pre-mRNA) splicing. This demonstrates that alternative 5' splice site selection can determine the protein product of a cellular gene. DM-20 mRNA is expressed in rat brain with approximately 50% abundance relative to PLP mRNA and appears to be developmentally coregulated.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-1105573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-1252461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-158758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2410136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2410294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2414013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2416470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2420640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2420930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2425262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2427200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2432393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2433693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2435545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2438699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2943217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-2946960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3017190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3466187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3467339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3469678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3779836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3840591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3840606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3916707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3922575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-3940288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-5072385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6159478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6193441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6195969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6201866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6252477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6300662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6313211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6315415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6337633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2441390-6642431
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5665-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2441390-Animals,
pubmed-meshheading:2441390-Mice,
pubmed-meshheading:2441390-Rats,
pubmed-meshheading:2441390-Protein Conformation,
pubmed-meshheading:2441390-Base Sequence,
pubmed-meshheading:2441390-Myelin Sheath,
pubmed-meshheading:2441390-RNA, Messenger,
pubmed-meshheading:2441390-Nerve Tissue Proteins,
pubmed-meshheading:2441390-Amino Acid Sequence,
pubmed-meshheading:2441390-Rats, Inbred Strains,
pubmed-meshheading:2441390-Proteolipids,
pubmed-meshheading:2441390-Transcription, Genetic,
pubmed-meshheading:2441390-Myelin Proteins,
pubmed-meshheading:2441390-Myelin Proteolipid Protein,
pubmed-meshheading:2441390-Mice, Jimpy,
pubmed-meshheading:2441390-RNA Splicing
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