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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
4
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|
pubmed:dateCreated |
1987-9-1
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|
pubmed:abstractText |
Methylation of either of two residues (G-1405 or A-1408) within bacterial 16 S ribosomal RNA results in high level resistance to specific combinations of aminoglycoside antibiotics. The product of a gene that originated in Micromonospora purpurea (an actinomycete that produces gentamicin) gives resistance to kanamycin plus gentamicin by converting residue G-1405 to 7-methylguanosine. Resistance to kanamycin plus apramycin results from conversion of residue A-1408 to 1-methyladenosine catalysed by the product of a gene from Streptomyces tenjimariensis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
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pubmed:issn |
0022-2836
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
20
|
|
pubmed:volume |
193
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
661-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2441068-Aminoglycosides,
pubmed-meshheading:2441068-Base Sequence,
pubmed-meshheading:2441068-Binding Sites,
pubmed-meshheading:2441068-Drug Resistance, Microbial,
pubmed-meshheading:2441068-Escherichia coli,
pubmed-meshheading:2441068-Methylation,
pubmed-meshheading:2441068-Methyltransferases,
pubmed-meshheading:2441068-Nucleic Acid Hybridization,
pubmed-meshheading:2441068-RNA,
pubmed-meshheading:2441068-RNA, Bacterial,
pubmed-meshheading:2441068-RNA, Ribosomal,
pubmed-meshheading:2441068-Streptomyces
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|
pubmed:year |
1987
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|
pubmed:articleTitle |
Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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