Linked Life Data

2441008

Source:http://linkedlifedata.com/resource/pubmed/id/2441008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1987-9-23
pubmed:abstractText
Cytoskeletal protein transport and metabolism are studied in the somatic motor and parasympathetic axons of the chicken oculomotor system. Kinetic analyses of pulse-labeled proteins indicate that the neurofilaments are transported 2-3 times more rapidly in the somatic motor axons than in the parasympathetic axons. By contrast, the transport rates of the slow component b (SCb) proteins are very similar in these axons. The parasympathetic axons terminate in the ciliary ganglion, and radiolabeling curves from the ciliary ganglion can be used to study the kinetics of cytoskeletal protein removal from the terminals. The rate of removal directly determines the residence time of the cytoskeletal proteins in the ciliary ganglion, and the residence time directly affects the shape and amplitude of the transport curves of the ganglion. A computer model was used to analyze these transport curves and to determine the half-residence time of the cytoskeletal proteins in the terminal regions. From the computer experiments, we estimate that the half-residence times of the neurofilament proteins actin and tubulin are 2, 3.5, and 7 d, respectively. The differences between the half-residence times of the cytoskeletal proteins indicate that the rate of protein removal from the terminals differs for these proteins. On the basis of these results, we propose that the removal mechanisms critically control the composition of the cytoskeleton in the terminal regions. Through their effects on its composition, the removal mechanisms have a crucial role in converting the cytoskeleton of the axon proper into the specialized cytoskeleton of the axon terminal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2397-411
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Axonal transport of cytoskeletal proteins in oculomotor axons and their residence times in the axon terminals.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't