Linked Life Data

2441000

Source:http://linkedlifedata.com/resource/pubmed/id/2441000

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-9-24
pubmed:abstractText
Immunohistochemistry has been used to demonstrate the presence of nerve growth factor (NGF)-like immunoreactivity in normal and sectioned mouse sciatic nerves. In normal nerves, immunoreactive material was not visible unless a silk ligature had previously been applied to constrict the nerves, and only then in the segment of nerve immediately distal to the ligation. Immunoreactivity was visible as early as 2 h after application of the ligature. When nerves were sectioned prior to ligation to prevent the transport of material from nerve terminals within innervated tissues, the NGF-like immunoreactivity continued to accumulate. This accumulation also occurred when a portion of the proximal stump from sectioned nerves was removed from the animal and placed in culture. Quantitative estimate of NGF concentrations with a sensitive immunoassay showed that the amount of NGF present within a segment of the proximal stump of sectioned nerves more than doubled in a 24 h period. The findings indicate that NGF is produced by cells within sectioned nerves, and further suggest that in the normal intact nerve at least a proportion of the NGF being transported derives from these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-4864
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Transport of endogenous nerve growth factor in the proximal stump of sectioned nerves.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't