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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1987-8-10
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pubmed:abstractText |
A liquid filament switch is described which can exchange the solution passing an excised outside-out patch of postsynaptic membrane within less than 1 ms. Application and washout of transmitter can be repeated at high rates. Results of such rapid activations by glutamate are shown for the excitatory and the inhibitory channel of crayfish muscle. The excitatory channel is activated within less than 0.5 ms, and after an initial peak of openings desensitizes with a time constant of 5 ms to a low steady-state level. A kinetic scheme of these reactions is proposed. The activation of the inhibitory channel is slower, and this channel desensitizes more slowly than the excitatory one.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
77
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-204
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2439957-Animals,
pubmed-meshheading:2439957-Astacoidea,
pubmed-meshheading:2439957-Chlorides,
pubmed-meshheading:2439957-Electrophysiology,
pubmed-meshheading:2439957-Glutamates,
pubmed-meshheading:2439957-Glutamic Acid,
pubmed-meshheading:2439957-Ion Channels,
pubmed-meshheading:2439957-Kinetics,
pubmed-meshheading:2439957-Muscles,
pubmed-meshheading:2439957-Synaptic Membranes,
pubmed-meshheading:2439957-gamma-Aminobutyric Acid
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pubmed:year |
1987
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pubmed:articleTitle |
Liquid filament switch for ultra-fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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