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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-8-13
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pubmed:abstractText |
We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins. Transfectants were tested by using CTL clone IE1 with specificity for an IE epitope presented in association with Ld. Data show that clone IE1 recognizes a product of the ie1 transcription unit of MCMV, and that its specificity is shared by approximately 25% of polyclonal IE-specific CTL. The results provide the first definite evidence that expression of a herpes virus IE gene encoding a regulatory protein gives rise to antigen expression detectable by specific CTL.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-2431160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-2985805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-2991554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-2999423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3001363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3001696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3005659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3027381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3029272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3033321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-3033334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-4365321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-6095095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-6281647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-6312075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-6319154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2439637-6328008
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2439637-Animals,
pubmed-meshheading:2439637-Antigens, Viral,
pubmed-meshheading:2439637-Cytomegalovirus,
pubmed-meshheading:2439637-DNA, Viral,
pubmed-meshheading:2439637-Epitopes,
pubmed-meshheading:2439637-Mice,
pubmed-meshheading:2439637-Mice, Inbred BALB C,
pubmed-meshheading:2439637-Peptides,
pubmed-meshheading:2439637-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2439637-Transcription, Genetic,
pubmed-meshheading:2439637-Transfection,
pubmed-meshheading:2439637-Viral Proteins
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pubmed:year |
1987
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pubmed:articleTitle |
A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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