Linked Life Data

2439270

Source:http://linkedlifedata.com/resource/pubmed/id/2439270

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-8-5
pubmed:abstractText
Of the occupational dermatoses, contact dermatitis is the most frequent. And the afferent limb of the antigen-specific delayed type hypersensitivity reaction seen in allergic contact dermatitis is induced by epidermal Langerhans cells (Lc). HLA-DR-positive Lc are probably the most important cells, capable of providing the initial alo-activating signal for skin graft rejection, and act as antigen-presenting cells for T cells, both with contact and microbial antigens, suggesting that they produce Interleukin 1. The amount of HLA-DR determinants is 50-100 times higher on Lc than on blood derived adherent cells, and they are more potent in inducing some antigen-specific T-cell responses. These antigen-specific T-cell responses are also restricted by HLA-D/DR antigens. UVB-radiation of Lc or preincubation with glucocorticosteroids reduces in a dose-dependent manner the Lc-induced T-cell responses to antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0343-2432
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The role of human epidermal Langerhans cells in skin immunity.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't