Linked Life Data

2438489

Source:http://linkedlifedata.com/resource/pubmed/id/2438489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-7-10
pubmed:abstractText
Studies were performed in normotensive volunteers and hypertensive subjects to examine the effect on forearm blood flow (FBF) of brachial artery infusions of angiotensin I (ANG I), angiotensin II (ANG II), and ramiprilat [the active metabolite of the angiotensin converting enzyme (ACE) inhibitor, ramipril]. Ramiprilat (10 mcg/min for 10 min) produced a 71% mean increase in FBF (n = 8; range, 26-130%; p less than 0.001) in vessels preconstricted with ANG I (64-128 pmol/min), with the effect maximal at the end of ramiprilat infusion and subsiding over 30 min. Doses of ANG I required to produce equivalent reductions of FBF were 2 to 4 times those of ANG II before ramiprilat, but after ramiprilat the dose of ANG I required to produce equivalent constriction was increased 20-fold (n = 6; p = 0.01) while that of ANG II was unaltered. Ramiprilat given alone produced only a small nonsignificant increase in FBF of 7 +/- 4% (n = 12; p = 0.29), though this increase did correlate significantly with plasma renin (r = 0.60; p = 0.04). These results confirm the presence of ACE within human resistance vessels and suggest the possibility that inhibition of ACE at sites other than the pulmonary bed might contribute to the hypotensive action of ACE inhibitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
8 Suppl 10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S40-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Vascular angiotensin conversion in humans.
pubmed:publicationType
Journal Article, Comparative Study