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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-5-28
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pubmed:abstractText |
The changes in monovalent cation fluxes induced by class 1 and class 2 heparin-binding growth factors purified from bovine brain were studied in confluent quiescent Balb/C 3T3 cells. Both classes of HBGF's rapidly stimulate the activity of the Na+-K+ pump in a concentration-dependent manner that parallels their mitogenic activity. This effect requires the presence of external Na+ and is abolished by 1 mM amiloride. As with other growth factors, HBGF's increase the activity of the Na+-K+ pump by increasing Na+ influx into the cells via the amiloride-sensitive Na+-H+ exchange. These results indicate that rapid activation of cation transport is an early cellular response that follows binding of HBGF's to specific receptors on the surface of target cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2437904-Animals,
pubmed-meshheading:2437904-Biological Transport, Active,
pubmed-meshheading:2437904-Cell Line,
pubmed-meshheading:2437904-Cell Membrane,
pubmed-meshheading:2437904-Fibroblast Growth Factors,
pubmed-meshheading:2437904-Growth Substances,
pubmed-meshheading:2437904-Heparin,
pubmed-meshheading:2437904-Ion Channels,
pubmed-meshheading:2437904-Mice,
pubmed-meshheading:2437904-Ouabain,
pubmed-meshheading:2437904-Potassium,
pubmed-meshheading:2437904-Rubidium,
pubmed-meshheading:2437904-Sodium
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pubmed:year |
1987
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pubmed:articleTitle |
Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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