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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-6-23
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pubmed:abstractText |
The glutamate receptor-channel of locust muscle membrane was studied using the patch-clamp technique. Muscles were pretreated with concanavalin A to block receptor-channel desensitization, thus facilitating analysis of receptor-channel gating kinetics. Single channel kinetics were analyzed to aid in identification of the molecular basis of channel gating. Channel dwell-time distributions and dwell-time autocorrelation functions were calculated from single channel data recorded in the precence of 10-4M glutamate. Analysis of the dwell time distributions in terms of mixtures of exponential functions revealed there to be at least three open states of the receptor-channel and at least four closed states. Autocorrelation function analysis showed there to be at least three pathways linking the open states with the closed. This results in a minimal scheme for gating of the glutamate receptor-channel, which is suggestive of allosteric models of receptor-channel gating.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-1083489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-1250383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-14343300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-227014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-22856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-2410047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-25739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-2580569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-3000517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-32745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-400609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-450063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-5018031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6048545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6111797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6113544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6120466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6139418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6142499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6144720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6207437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6248795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6261141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6273743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6276768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6281357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6301575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6316158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6324899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6324900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6324902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6328531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2436676-6720989
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2436676-Animals,
pubmed-meshheading:2436676-Glutamates,
pubmed-meshheading:2436676-Grasshoppers,
pubmed-meshheading:2436676-Ion Channels,
pubmed-meshheading:2436676-Kinetics,
pubmed-meshheading:2436676-Mathematics,
pubmed-meshheading:2436676-Models, Biological,
pubmed-meshheading:2436676-Muscles,
pubmed-meshheading:2436676-Receptors, Glutamate,
pubmed-meshheading:2436676-Receptors, Neurotransmitter
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pubmed:year |
1987
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pubmed:articleTitle |
Single channel kinetics of a glutamate receptor.
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pubmed:publicationType |
Journal Article,
Corrected and Republished Article
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