Linked Life Data

2436100

Source:http://linkedlifedata.com/resource/pubmed/id/2436100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-4-29
pubmed:abstractText
The influence of chronic arthritic pain upon the levels of mRNA encoding prodynorphin (mRNADYN) in the spinal cord of rats was evaluated by use of the RNA blot technique. Rats were rendered arthritic by inoculation of the tail-base with a suspension of Mycobacterium butyricum. Three weeks post inoculation, levels of mRNADYN revealed a pronounced alteration in arthritic rats by a factor of greater than or equal to 2.5 as compared to control animals. This rise was specific in that there was no change in total RNA content. These data indicate that the biosynthetic activity of the dynorphin system is facilitated under chronic pain. Together with our previous biochemical and behavioural data, a functional role of this system in the response to chronic pain is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Prodynorphin gene expression is enhanced in the spinal cord of chronic arthritic rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't