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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-5-12
|
| pubmed:abstractText |
Depression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0340-5354
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
234
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
94-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2435855-Aged,
pubmed-meshheading:2435855-Depressive Disorder,
pubmed-meshheading:2435855-Female,
pubmed-meshheading:2435855-Humans,
pubmed-meshheading:2435855-Hydroxyindoleacetic Acid,
pubmed-meshheading:2435855-Male,
pubmed-meshheading:2435855-Middle Aged,
pubmed-meshheading:2435855-Parkinson Disease,
pubmed-meshheading:2435855-Serotonin
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Depression and Parkinson's disease: possible role of serotonergic mechanisms.
|
| pubmed:publicationType |
Journal Article
|