Linked Life Data

2435495

Source:http://linkedlifedata.com/resource/pubmed/id/2435495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-5-21
pubmed:abstractText
Chronic inhalation studies of diesel exhaust (SPM 4.9 + 1.6 mg m-3) on SPF Fischer 344 rats were carried out to elucidate its effect on health. The most prominent changes observed were proliferative change of type II alveolar epithelium and respiratory bronchiolar epithelium which appeared after 6 months of exposure, and extended according to the exposure duration to whole exhaust. Neoplastic changes were found in 2-year-exposed rats, some of them being malignant. The rate of malignant tumors was higher in the rats observed for 6 months after 2 years of exposure to whole exhaust. Malignant lymphoma with a highly frequent complication of leukemia was the main cause of death in the rats exposed to filtered as well as whole exhaust, and the rate was significantly higher than that of the control group. Mammary adenoma and fibroma were seen more in the exposed groups than in the control group and multi-tumors were noted only in both exposed groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0165-2214
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Long-term inhalation studies of diesel exhaust on F344 SPF rats. Incidence of lung cancer and lymphoma.
pubmed:publicationType
Journal Article