|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8532
|
|
pubmed:dateCreated |
1987-4-6
|
|
pubmed:abstractText |
In a double-blind, randomised trial Org 10172 low-molecular-weight (LMW) heparinoid was compared with placebo in the prevention of deep-vein thrombosis in patients with acute thrombotic stroke. Prophylaxis was started within 7 days of the onset of stroke with a loading dose of 1000 anti-factor-Xa units intravenously followed by a fixed dose of 750 anti-factor-Xa units twice a day subcutaneously; it was continued for 14 days or until hospital discharge, if earlier. 50 patients were randomised to receive Org 10172 and 25 to receive placebo. All patients underwent surveillance with I125-fibrinogen leg scanning and impedance plethysmography. Venography was carried out if either test became positive. Venous thrombosis occurred in 2 of 50 patients (4.0%) given Org 10172 and 7 of 25 patients (28.0%) given placebo (p = 0.005); the corresponding rates of proximal-vein thrombosis were 0% and 16%, respectively (p = 0.01). There was one major haemorrhage in the Org 10172 group and one minor bleed in the placebo group.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
523-6
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2434815-Acute Disease,
pubmed-meshheading:2434815-Adult,
pubmed-meshheading:2434815-Aged,
pubmed-meshheading:2434815-Aged, 80 and over,
pubmed-meshheading:2434815-Cerebrovascular Disorders,
pubmed-meshheading:2434815-Chondroitin Sulfates,
pubmed-meshheading:2434815-Clinical Trials as Topic,
pubmed-meshheading:2434815-Dermatan Sulfate,
pubmed-meshheading:2434815-Female,
pubmed-meshheading:2434815-Fibrinolytic Agents,
pubmed-meshheading:2434815-Follow-Up Studies,
pubmed-meshheading:2434815-Glycosaminoglycans,
pubmed-meshheading:2434815-Heparin,
pubmed-meshheading:2434815-Heparinoids,
pubmed-meshheading:2434815-Heparitin Sulfate,
pubmed-meshheading:2434815-Humans,
pubmed-meshheading:2434815-Injections, Intravenous,
pubmed-meshheading:2434815-Injections, Subcutaneous,
pubmed-meshheading:2434815-Male,
pubmed-meshheading:2434815-Middle Aged,
pubmed-meshheading:2434815-Random Allocation,
pubmed-meshheading:2434815-Thrombosis,
pubmed-meshheading:2434815-Time Factors
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
