Linked Life Data

2434681

Source:http://linkedlifedata.com/resource/pubmed/id/2434681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-4-21
pubmed:abstractText
Single Ca channel currents were recorded from isolated guinea pig ventricular myocytes in the presence of 50 mM Ba by the patch clamp technique under cell-attached configuration. When a constant short depolarizing pulse was applied repetitively, a single Ca channel opened in bursts during some depolarizing steps but completely failed to open in other steps. The opening probability of Ca channels in current-containing sweeps was little affected by adrenaline. There was a tendency for either failure, or success, in inducing a burst, to occur in clusters. The histogram of the number of successes between two failures showed a single exponential distribution with a time constant of 1-2 sec in controls and 2-4 sec in the presence of adrenaline (2 X 10(-6) M). The mean number of failures between two successes was diminished considerably by adrenaline. In ventricular myocytes adrenaline seems to increase the Ca current mainly by decreasing the rate of the Ca channel for the transition between one mode at which the channel is allowed to open on depolarization and other modes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-4868
pubmed:author
pubmed:issnType
Print
pubmed:volume
27 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Beta-adrenergic modulation of the slow gating process of cardiac calcium channels.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't