| pubmed-article:2434514 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2434514 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:2434514 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2434514 | pubmed:dateCreated | 1987-4-8 | lld:pubmed |
| pubmed-article:2434514 | pubmed:abstractText | Schwann cell proliferation induced by a myelin-enriched fraction was examined in vitro. Although nearly all the Schwann cells contained material that was recognized by antisera to myelin basic protein after 24 h, only 1% of the cells were synthesizing DNA. 72 h after the addition of the mitogen a maximum of 10% of the cells incorporated [3H]thymidine. If the cultures were treated with the myelin-enriched fraction for 24 h and then washed, the number of proliferating Schwann cells decreased by 75% when compared with those cells that were incubated with the mitogen continuously. When Schwann cells were labeled with [14C]thymidine followed by a pulse of [3H]thymidine 24 h later, every Schwann cell labeled with [3H]thymidine was also labeled with [14C]thymidine. Although almost every Schwann cell can metabolize the myelin membranes within 24 h of exposure, a small population of cell initially utilizes the myelin as a mitogen, and this population continues to divide only if myelin is present in the extracellular media. The percentage of the Schwann cells that initially recognize the myelin-enriched fraction as a mitogen is dependent upon the age of the animal from which the cells were prepared. | lld:pubmed |
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| pubmed-article:2434514 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2434514 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2434514 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2434514 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2434514 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2434514 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2434514 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:2434514 | pubmed:author | pubmed-author:DeVriesG HGH | lld:pubmed |
| pubmed-article:2434514 | pubmed:author | pubmed-author:MasonP WPW | lld:pubmed |
| pubmed-article:2434514 | pubmed:author | pubmed-author:YoshinoJ EJE | lld:pubmed |
| pubmed-article:2434514 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2434514 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:2434514 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2434514 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2434514 | pubmed:pagination | 655-60 | lld:pubmed |
| pubmed-article:2434514 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2434514 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2434514 | pubmed:articleTitle | Developmental changes in myelin-induced proliferation of cultured Schwann cells. | lld:pubmed |
| pubmed-article:2434514 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2434514 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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