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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-3-30
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pubmed:abstractText |
The cytosolic and mitochondrial contents in ATP, ADP and AMP were measured in islets incubated for 45 min at increasing concentrations of D-glucose and then exposed for 20 s to digitonin. The latter treatment failed to affect the total islet ATP/ADP ratio and adenylate charge. D-Glucose caused a much greater increase in cytosolic than mitochondrial ATP/ADP ratio. In the cytosol, a sigmoidal pattern characterized the changes in ATP/ADP ratio at increasing concentrations of D-glucose. These findings are compatible with the view that cytosolic ATP participates in the coupling of metabolic to ionic events in the process of nutrient-induced insulin release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
927
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2434137-Adenosine Diphosphate,
pubmed-meshheading:2434137-Adenosine Monophosphate,
pubmed-meshheading:2434137-Adenosine Triphosphate,
pubmed-meshheading:2434137-Animals,
pubmed-meshheading:2434137-Cytosol,
pubmed-meshheading:2434137-Digitonin,
pubmed-meshheading:2434137-Glucose,
pubmed-meshheading:2434137-Glutamate Dehydrogenase,
pubmed-meshheading:2434137-Insulin,
pubmed-meshheading:2434137-Ion Channels,
pubmed-meshheading:2434137-Islets of Langerhans,
pubmed-meshheading:2434137-L-Lactate Dehydrogenase,
pubmed-meshheading:2434137-Mitochondria,
pubmed-meshheading:2434137-Potassium,
pubmed-meshheading:2434137-Rats
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pubmed:year |
1987
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pubmed:articleTitle |
Glucose-induced changes in cytosolic ATP content in pancreatic islets.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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