Linked Life Data

2433956

Source:http://linkedlifedata.com/resource/pubmed/id/2433956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-3-18
pubmed:abstractText
The electrophysiological effects of aldehydes derived from several monoamines were studied on single neurons in the cerebellum and neocortex of rats. The aldehydes derived from dopamine (3,4-dihydroxyphenylacetaldehyde) and serotonin (5-hydroxy-3-acetaldehyde) were prepared as stable disulfite complexes, from which free aldehydes were extracted. Serotonin and 5-hydroxy-3-acetaldehyde caused pronounced depression of firing rates both of cerebellar Purkinje neurons and neurons in prefrontal cortex. When locally applied from multibarrel micropipettes by pressure ejection, 5-hydroxy-3-acetaldehyde was twice as potent in the neocortex as in the cerebellum, and was equipotent with serotonin in both brain areas. The aldehyde of tryptamine also caused depressions of neuronal activity in cerebellum, but only at 5-fold higher doses than were effective for 5-hydroxy-3-acetaldehyde. 3,4-Dihydroxyphenylacetaldehyde was without effect in prefrontal cortex, but had mixed responses in the cerebellum. The results show that monoamine-derived aldehydes are physiologically active. It is possible that changes in the steady state level of these aldehydes caused by drugs such as ethanol and barbiturates might influence the electrophysiological properties of neurons in the central nervous system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0145-6008
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
682-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Electrophysiological effects of monoamine-derived aldehydes on single neurons in neocortex and cerebellum in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't