| pubmed-article:2433656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C0017601 | lld:lifeskim |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C0016360 | lld:lifeskim |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C1522577 | lld:lifeskim |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C0242673 | lld:lifeskim |
| pubmed-article:2433656 | lifeskim:mentions | umls-concept:C0031928 | lld:lifeskim |
| pubmed-article:2433656 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2433656 | pubmed:dateCreated | 1987-3-19 | lld:pubmed |
| pubmed-article:2433656 | pubmed:abstractText | Ninety-five patients (104 eyes) were enrolled in a pilot study of subconjunctival 5-fluorouracil (5-FU) injections after filtering surgery in eyes with poor surgical prognoses. At least a six-month follow-up was available on 84 patients, of whom four were excluded from the analysis of surgical outcome because they suffered retinal detachments within six months of their filtering surgery. The initial 5-FU procedures on the remaining 80 patients were successful (no further glaucoma surgical procedures were either performed or recommended, and the intraocular pressures [IOPs] were either 21 mmHg or lower with ocular hypotensive medication[s] or 25 mmHg or lower without ocular hypotensive medication) in 33 (68%) of the 48 aphakic eyes with non-neovascular glaucomas, 13 (81%) of the 16 phakic eyes with non-neovascular glaucomas after unsuccessful filtering surgery, and 12 (75%) of the 16 eyes with neovascular glaucoma (NVG). The follow-up on the successful eyes ranged from 6 to 34 months (mean +/- SD = 18.5 +/- 7.5). The visual acuities remained within one line of their preoperative levels or improved in 38 (79%) of the 48 aphakic eyes with non-neovascular glaucoma, 11 (69%) of the 16 phakic eyes with non-neovascular glaucoma after unsuccessful filtering surgery, and 12 (75%) of the 16 eyes with NVG. The initial 5-FU procedures on the 104 eyes were complicated by the following: corneal epithelial defects (50%); conjunctival wound and suture tract leaks (36%; 2% underwent surgical repair); suprachoroidal hemorrhages (9%); retinal detachments (3%); subepithelial corneal scarring (3%); endophthalmitis (2%); and malignant glaucoma (1%). It is the authors' impression that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control after filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this impression. | lld:pubmed |
| pubmed-article:2433656 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2433656 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2433656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2433656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2433656 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2433656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2433656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2433656 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2433656 | pubmed:issn | 0161-6420 | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:PalmbergP FPF | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:RockwoodE JEJ | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:GresselM GMG | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:HeuerD KDK | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:ParrishR... | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:SkutaG LGL | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:HodappEE | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:DesjardinsD... | lld:pubmed |
| pubmed-article:2433656 | pubmed:author | pubmed-author:NevárezJ AJA | lld:pubmed |
| pubmed-article:2433656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2433656 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:2433656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2433656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2433656 | pubmed:pagination | 1537-46 | lld:pubmed |
| pubmed-article:2433656 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:meshHeading | pubmed-meshheading:2433656-... | lld:pubmed |
| pubmed-article:2433656 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2433656 | pubmed:articleTitle | 5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study. | lld:pubmed |
| pubmed-article:2433656 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2433656 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2433656 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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