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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-3-11
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pubmed:abstractText |
The antigen-mediated induction of heparanase, an endoglycosidase capable of degrading heparan sulfate from the subendothelial extracellular matrix (ECM), was investigated in a rat T lymphocyte cell line reactive against the basic protein (BP) of myelin. We found that nonactivated T lymphocytes could be induced to express heparanase activity following exposure to soluble but not to ECM-bound BP. The induction of heparanase was immunologically specific and independent of the presence of syngeneic or allogeneic antigen presenting cells (APC). However, anti-IA antibodies inhibited heparanase expression. Soluble BP induced secretion of heparanase into the culture medium within minutes, despite inhibition of protein synthesis. Cell lysates of T lymphocytes contained heparanase activity. Thus, T lymphocytes secrete a preformed heparanase following exposure to specific antigen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2433294-Animals,
pubmed-meshheading:2433294-Antibodies,
pubmed-meshheading:2433294-Cattle,
pubmed-meshheading:2433294-Cell Line,
pubmed-meshheading:2433294-Cells, Cultured,
pubmed-meshheading:2433294-Cornea,
pubmed-meshheading:2433294-Cycloheximide,
pubmed-meshheading:2433294-Endothelium,
pubmed-meshheading:2433294-Enzyme Induction,
pubmed-meshheading:2433294-Extracellular Matrix,
pubmed-meshheading:2433294-Glucuronidase,
pubmed-meshheading:2433294-Glycosaminoglycans,
pubmed-meshheading:2433294-Glycoside Hydrolases,
pubmed-meshheading:2433294-Heparitin Sulfate,
pubmed-meshheading:2433294-Male,
pubmed-meshheading:2433294-Myelin Basic Proteins,
pubmed-meshheading:2433294-Rats,
pubmed-meshheading:2433294-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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