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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1986-12-17
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pubmed:abstractText |
Mechanical responses elicited by rat interferon (IFN) were investigated in rat vascular smooth muscle cells (RVSMC) in primary culture. IFN induced a dose-dependent reduction in the apparent cell surface area, which was quantitatively comparable to, or even greater than, the response elicited by the alpha-adrenergic agent, phenylephrine. Neither mock-IFN nor rat IFN-neutralized with specific antibodies elicited such a response. The sensitivity of RVSMC to the mechanical effect of IFN was species specific. In addition, the effect of IFN was inhibited by the Ca2+ entry blocker, verapamil.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0197-8357
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-404
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2430030-Animals,
pubmed-meshheading:2430030-Calcium,
pubmed-meshheading:2430030-Cells, Cultured,
pubmed-meshheading:2430030-Interferons,
pubmed-meshheading:2430030-Male,
pubmed-meshheading:2430030-Muscle, Smooth, Vascular,
pubmed-meshheading:2430030-Phenylephrine,
pubmed-meshheading:2430030-Rats,
pubmed-meshheading:2430030-Rats, Inbred Strains,
pubmed-meshheading:2430030-Verapamil
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pubmed:year |
1986
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pubmed:articleTitle |
Mechanical responses of rat vascular smooth muscle cells to rat interferon.
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pubmed:publicationType |
Journal Article,
Comparative Study
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