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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1986-12-10
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pubmed:abstractText |
Using an ELISA technique, changes in specific antibody levels against pneumococcal serotypes 1, 4, 7F, 14, 18C and 23F were studied in 8 adults healthy at the time of investigation but splenectomized previously because of hematological disease following infusion of 200 mg/kg body weight of a commercially available immunoglobulin preparation for intravenous use (Sandoglobulin). Among the 4 patients with initially low serum levels of antipneumococcal antibodies, significantly raised antibody levels were demonstrated against type 14 for 8 weeks. On the other hand, the infusion did not lead to increased antibody levels in 3 patients with high preinfusion values for antipneumococcal antibodies. In contrast, a significantly lower antibody value for type 7F was recorded 3 weeks after infusion. Efficacy of immunoglobulin prophylaxis is, therefore, probably doubtful in certain splenectomized patients, and if contemplated should be preceded by analysis of antibody levels against common pathogens.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0020-5915
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-13
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:2429931-Adolescent,
pubmed-meshheading:2429931-Adult,
pubmed-meshheading:2429931-Anemia, Hemolytic, Congenital,
pubmed-meshheading:2429931-Antibodies, Bacterial,
pubmed-meshheading:2429931-Female,
pubmed-meshheading:2429931-Humans,
pubmed-meshheading:2429931-Immunization, Passive,
pubmed-meshheading:2429931-Male,
pubmed-meshheading:2429931-Middle Aged,
pubmed-meshheading:2429931-Purpura, Thrombocytopenic,
pubmed-meshheading:2429931-Splenectomy,
pubmed-meshheading:2429931-Streptococcus pneumoniae,
pubmed-meshheading:2429931-gamma-Globulins
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pubmed:year |
1986
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pubmed:articleTitle |
Effect of gamma globulin infusion on type-specific pneumococcal antibody levels in splenectomized adults.
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pubmed:publicationType |
Journal Article
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