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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6088
|
pubmed:dateCreated |
1986-11-12
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pubmed:databankReference | |
pubmed:abstractText |
Hepatitis delta (delta) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing approximately 25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
323
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
558-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2429192-Base Sequence,
pubmed-meshheading:2429192-Cloning, Molecular,
pubmed-meshheading:2429192-DNA,
pubmed-meshheading:2429192-Hepatitis Delta Virus,
pubmed-meshheading:2429192-Microscopy, Electron,
pubmed-meshheading:2429192-RNA,
pubmed-meshheading:2429192-RNA, Viral,
pubmed-meshheading:2429192-Sequence Homology, Nucleic Acid
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pubmed:articleTitle |
The hepatitis delta (delta) virus possesses a circular RNA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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