Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1986-11-18
pubmed:abstractText
The ability of synthetic P. falciparum (NANP)n circumsporozoite peptides to elicit murine T cell proliferative responses was studied. When C57BL/6, C3H, and DBA/2 mice were injected with (NANP)40, only C57BL/6 (H-2b)-immune lymph node cells proliferated on restimulation in vitro with the same peptide. By using anti-I-A monoclonal antibodies or spleen cells from congenic H-2b mice as a source of antigen-presenting cells, the T cell proliferative response was shown to be restricted to the I-Ab region of the C57BL/6 haplotype. These results are in agreement with previous experiments which demonstrated that the anti-(NANP)40 antibody response was uniquely restricted to C57BL/6 (H-2b) mice. Several C57BL/6 long-term (NANP)n-specific T cell lines and clones were derived. All of the clones exhibited the L3T4 helper T cell phenotype. A considerable heterogeneity of T cell responses was observed when the lines and clones were stimulated with different concentrations of the various peptides studied. The results, together with the observed genetic restriction for both antibody and T cell responses, suggest that perhaps not all individuals who receive a similar repetitive tetrapeptide sporozoite malaria vaccine will develop T cell and or antibody responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2956-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2428881-Animals, pubmed-meshheading:2428881-Antibody Formation, pubmed-meshheading:2428881-Antigens, pubmed-meshheading:2428881-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:2428881-Antigens, Protozoan, pubmed-meshheading:2428881-Antigens, Surface, pubmed-meshheading:2428881-Epitopes, pubmed-meshheading:2428881-H-2 Antigens, pubmed-meshheading:2428881-Lymph Nodes, pubmed-meshheading:2428881-Lymphocyte Activation, pubmed-meshheading:2428881-Mice, pubmed-meshheading:2428881-Mice, Inbred C57BL, pubmed-meshheading:2428881-Molecular Weight, pubmed-meshheading:2428881-Peptides, pubmed-meshheading:2428881-Plasmodium falciparum, pubmed-meshheading:2428881-Structure-Activity Relationship, pubmed-meshheading:2428881-T-Lymphocytes, pubmed-meshheading:2428881-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:2428881-Vaccines, Synthetic
pubmed:year
1986
pubmed:articleTitle
Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't