Linked Life Data

2428786

Source:http://linkedlifedata.com/resource/pubmed/id/2428786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-11-7
pubmed:abstractText
T-cell lines specific for purified tuberculin (PPD), rubella, and herpes simplex virus (HSV) antigens were established from two Dw1/w2 heterozygous subjects. Fresh peripheral blood monocytes from healthy individuals with shared and non-shared D-antigens were used as presenting cells and the T-cell lines as responders in lymphocyte blast transformation assays with specific antigens. An HLA-restricted reaction was seen with all the antigens, although the PPD- and HSV-specific cell lines reacted stronger than rubella-specific lines when the specific antigens were presented by monocytes not sharing the D-antigens. A significantly lower response was seen when rubella antigen was presented by Dw2 positive monocytes as compared to response promoted by Dw1 positive monocytes (p less than 0.0001, Mann-Whitney U-test), whereas no such difference was seen in responses to PPD or herpes simplex antigen.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
94-101
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Comparison of HLA-Dw1 and -Dw2 positive adherent cells in antigen presentation to heterozygous T-cell lines: a low rubella antigen-specific response associated with HLA-Dw2.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't