Linked Life Data

2428724

Source:http://linkedlifedata.com/resource/pubmed/id/2428724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-11-3
pubmed:abstractText
Ninety per cent of patients infected in adult life with the hepatitis B virus clear the virus completely and 10% develop chronic infection. There is evidence for the involvement of interferon in the clearance of acute hepatitis B virus infection. We report that, in in vitro tests, some hepatitis B virus carriers have a reduced capacity to produce alpha- and gamma-interferon which is unrelated to the level of viral replication and to the severity of the liver disease and that the level of 2-5 oligoadenylate synthetase in their livers is only minimally elevated compared to controls. Treatment with lymphoblastoid (alpha-) interferon leads to a marked rise in 2-5 oligoadenylate synthetase activity. These data indicate that some patients with chronic hepatitis B virus infection acquired in adult life have a partial deficiency of production of alpha-interferon but can respond to exogenous alpha-interferon. These observations provide a logical basis for attempts to treat this condition with interferons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-9139
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
962-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't