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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1986-11-14
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pubmed:abstractText |
The isolation of multispecific B cell hybridomas with a variety of anti-idiotype (anti-Id) activities from the lymphoid organs of fetal and neonatal BALB/c mice suggested that the development of the immune system may depend on Id interactions among autologous B cells. In vitro analysis of antibodies secreted by these hybridomas showed extensive sharing of an idiotope defined by the monoclonal antibody FD5-1. Early and timed administration of this antibody during the perinatal period results in a distortion of the phosphorylcholine (PC) and alpha (1----3)dextran (Dex)-specific B cell precursor compartment of the developing repertoire and is reflected by a drastic reduction of antibody responses to these antigens when challenged as adults. These observations provide strong evidence for the involvement of the early appearing multispecific B cells in Id interactions that bring about the uniform development of the normal adult B cell repertoire. Interference with these interactions at critical stages of developmental results in permanent deficiencies in the adult B cell repertoire.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1159-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2428628-Animals,
pubmed-meshheading:2428628-Animals, Newborn,
pubmed-meshheading:2428628-Antibodies, Monoclonal,
pubmed-meshheading:2428628-Autoantibodies,
pubmed-meshheading:2428628-B-Lymphocytes,
pubmed-meshheading:2428628-Dextrans,
pubmed-meshheading:2428628-Fetus,
pubmed-meshheading:2428628-Immunoglobulin Heavy Chains,
pubmed-meshheading:2428628-Immunoglobulin Idiotypes,
pubmed-meshheading:2428628-Immunoglobulin M,
pubmed-meshheading:2428628-Immunoglobulin Variable Region,
pubmed-meshheading:2428628-Mice,
pubmed-meshheading:2428628-Mice, Inbred BALB C,
pubmed-meshheading:2428628-Peptide Mapping,
pubmed-meshheading:2428628-Phosphorylcholine,
pubmed-meshheading:2428628-T-Lymphocytes,
pubmed-meshheading:2428628-Trinitrobenzenes
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pubmed:year |
1986
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pubmed:articleTitle |
In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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