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pubmed:abstractText |
Both naloxone hydrochloride and the quaternary compound, naloxone methylbromide, significantly reduced antinociception elicited by 90 s of continuous footshock. Peripheral specificity of quaternary naloxone was demonstrated by its lack of antagonism of morphine analgesia. These results suggest that a significant portion of the antinociception elicited by these parameters of footshock and assessed by tail-flick procedures in rats is due to the activation of peripheral endorphins.
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