Linked Life Data

2428357

Source:http://linkedlifedata.com/resource/pubmed/id/2428357

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-10-10
pubmed:abstractText
The acute phase response (APR) induced by immune complexes or turpentine and modulated by dexamethasone as well as adrenaline was investigated in intact, sham-adrenalectomized and adrenalectomized rats. The serum level of alpha 2-acute phase globulin was examined by means of electroimmunodiffusion, and the complex serum protein profile was studied using the crossed-IE. Dexamethasone administration increased the alpha 2-acute phase globulin concentration weakly over a wide dose range whereas rats dosed with adrenaline responded strongly over a small dose range. Turpentine but not immune complex challenge provoked an almost complete acute phase protein profile as well as a moderate alpha 2-acute phase globulin elevation in adrenalectomized rats. After combined administration of the prophlogistic agents and dexamethasone or adrenaline a remarkably high alpha 2-acute phase globulin level was found (up to 14 mg/ml with about 0.05 mg/ml as base level). From these results a synergistic mode of action can be suggested. With crossed-IE some of the proteins could by divided in proteins responding in a glucocorticoid-dependent (e.g. alpha 2-acute phase globulin, haptoglobin) and -independent fashion (alpha 1-acute phase globulin), respectively. It can be concluded that glucocorticoids, catecholamines as well as cytokines are the main candidates for triggering the acute phase response; however, additional factors may also be of importance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
661-72
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Modulation of alpha 2-acute phase globulin serum concentration in turpentine- and immune complex-challenged rats by dexamethasone and adrenaline: evidence for a synergistic mode of action.
pubmed:publicationType
Journal Article