Linked Life Data

2427155

Source:http://linkedlifedata.com/resource/pubmed/id/2427155

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-9-30
pubmed:abstractText
Three monoclonal antibodies (mAbs) raised against the leech CNS recognize surface antigens on small sets and subsets of neurons or on glial cells. On immunoblots, they all recognize proteins of 130 kDa molecular weight. In addition, they each bind up to several different lower molecular weight forms. The 130 kDa polypeptides recognized by these mAbs are not major proteins on Coomassie blue-stained gels. They behave as glycoproteins on lentil lectin columns but are not major Concanavalin A-binding molecules. These molecules therefore represent a group of lower abundance, cell-type-specific antigens. Structural relationships between these antigens were explored using immunoprecipitation. The glial cell antigen was immunopurified, however, a fraction of the neuronal antigens co-precipitate. The co-precipitation of neuronal antigens raises the possibility that different neuronal antigenic determinants are carried on the same protein molecule. Such a protein may be modified to carry either one or both neuronal determinants, and could serve as a tag to physiologically delineate subsets of neurons nested within larger neuronal sets.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
378
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Probing structural homologies in cell-specific glycoproteins in the leech CNS.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't