Linked Life Data

2426845

Source:http://linkedlifedata.com/resource/pubmed/id/2426845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-17
pubmed:abstractText
These studies constitute the first report of a comparison of the ability of a population of antigen-specific helper factors (ASHF) to induce cell-mediated and humoral immune responses. Supernatants of helper T lymphocyte (TH) cell lines, were purified by antigen-affinity chromatography and tested for their ability to induce cytotoxic T lymphocyte (CTL) responses and IgM responses in vitro. The supernatant of a noncloned TH line was found to contain two functionally distinct types of ASHF that are separable by anion-exchange chromatography: one factor triggers CTL responses (ASHFCTL), the other triggers IgM B cell responses (ASHFB). Clone 4C6, derived from the parent line CHI, produces ASHFCTL but not ASHFB. These observations could result from two entirely distinct ASHF or from the association of common antigen-specific subunits with different antigen-nonspecific subunits to make ASHFCTL or ASHFB.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Functional activity of soluble antigen-specific helper T cell molecules. Requirement for separable entities for the induction of cytotoxic T cell and B cell responses.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't