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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1986-9-25
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pubmed:abstractText |
Polyoma middle T antigen (mT) was expressed in rat F-111 cells under control of the dexamethasone-regulatable mouse mammary tumor virus promoter. Graded phenotypic responses to levels of mT induction by the hormone were seen, with morphological transformation, focus formation, and anchorage-independent growth requiring increasing levels of mT expression. The ability of different clones to form tumors reflected their maximum level of induction of mT-associated kinase and their ability to grow in soft agar. Expression of transformation parameters and tumorigenicity correlates with the level of mT phosphorylated by pp60c-src in immune complexes and not with the total amount of mT determined by metabolic labeling. We suggest that cellular factors regulate mT activity by forming a kinase-active fraction of mT molecules that controls the transformed state.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-191634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-201774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-203944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-210955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-214241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-223300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-225559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-229973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-229974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-2987799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-4134493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-4364825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-4442124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6091899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6091900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6092668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6098822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6169848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6179082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6184609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6272123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6275112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6277498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6288960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6294529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6294653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6304524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6305416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6305596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6308618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6320286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6321764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6322850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-6605480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-7096324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426583-9279398
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Polyomavirus Transforming,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral, Tumor,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins pp60(c-src),
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2476-86
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2426583-Animals,
pubmed-meshheading:2426583-Antigens, Polyomavirus Transforming,
pubmed-meshheading:2426583-Antigens, Viral, Tumor,
pubmed-meshheading:2426583-Cell Adhesion,
pubmed-meshheading:2426583-Cell Line,
pubmed-meshheading:2426583-Cell Transformation, Viral,
pubmed-meshheading:2426583-Dexamethasone,
pubmed-meshheading:2426583-Fibroblasts,
pubmed-meshheading:2426583-Gene Expression Regulation,
pubmed-meshheading:2426583-Genes, Synthetic,
pubmed-meshheading:2426583-Male,
pubmed-meshheading:2426583-Mammary Tumor Virus, Mouse,
pubmed-meshheading:2426583-Neoplasm Transplantation,
pubmed-meshheading:2426583-Oncogene Proteins, Viral,
pubmed-meshheading:2426583-Phenotype,
pubmed-meshheading:2426583-Polyomavirus,
pubmed-meshheading:2426583-Promoter Regions, Genetic,
pubmed-meshheading:2426583-Protein Kinases,
pubmed-meshheading:2426583-Proto-Oncogene Proteins,
pubmed-meshheading:2426583-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:2426583-Rats,
pubmed-meshheading:2426583-Recombinant Proteins
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pubmed:year |
1985
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pubmed:articleTitle |
Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts.
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pubmed:publicationType |
Journal Article
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