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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1986-9-25
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pubmed:abstractText |
Fifteen independent ICR-170-induced his4 mutations in Saccharomyces cerevisiae were examined by DNA sequence analysis. All of the mutations contained a +1 G-C base pair addition in the HIS4 coding region. Eleven different sites of insertion were identified. Combined with previous DNA sequence data, 21 ICR-170-induced his4 mutations distributed at 16 different sites were analyzed. The insertions were always located in a consecutive run of two or more G-C base pairs, with all base pairs in each run having identical orientation. Long consecutive G-C runs were preferred target sites over short runs. Although some consecutive G-C runs appeared to be preferred target sites over others of identical length, such preference was not due to any particular type of nucleotide pair immediately adjacent to a given target site. In addition, DNA sequence analyses of the his4 mutations provided a basis for examining the mechanism of mRNA sequence recognition by extragenic suppressors of ICR-170-induced mutations. The implications of these results for mechanisms of frameshift suppression are discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-17246112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-365691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-388356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-388424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-388431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-3894935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-4603162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-4866378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-5237214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-533897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6159575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6251232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6336730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6390183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6449009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6757051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-6757053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7010605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7040679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7048310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7049842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-72702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7402305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7433120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426578-7443522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2247-56
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:2426578-Aminoacridines,
pubmed-meshheading:2426578-Base Composition,
pubmed-meshheading:2426578-Cloning, Molecular,
pubmed-meshheading:2426578-DNA, Fungal,
pubmed-meshheading:2426578-Genes, Fungal,
pubmed-meshheading:2426578-Mutation,
pubmed-meshheading:2426578-Nitrogen Mustard Compounds,
pubmed-meshheading:2426578-Saccharomyces cerevisiae,
pubmed-meshheading:2426578-Suppression, Genetic
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pubmed:year |
1985
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pubmed:articleTitle |
Suppressible and nonsuppressible +1 G-C base pair insertions induced by ICR-170 at the his4 locus in Saccharomyces cerevisiae.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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