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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-9-17
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pubmed:abstractText |
BALB/c mice immunized with Pseudomonas aeruginosa immunotype 1 polysaccharide develop protective T cell immunity to bacterial challenge. In vitro, T cells from immunized mice kill P. aeruginosa by production of a bactericidal lymphokine. The present study demonstrates that adoptive transfer of T cells from immunized BALB/c mice to granulocytopenic mice resulted in 97% survival on challenge with P. aeruginosa, compared with 17% survival with adoptive transfer of T cells from nonimmune BALB/c mice. This protection is specifically elicited by reexposure to the original immunizing antigen; adoptive recipients cannot withstand challenge with immunotype 3 P. aeruginosa. However, the adoptive recipients do survive simultaneous infection with both P. aeruginosa immunotypes 1 and 3. Adoptive transfer of T cells from the congenic CB.20 mice, which are unable to kill P. aeruginosa in vitro, provides only 20% protection to granulocytopenic mice. These studies indicate that transfer of specific immune T lymphocytes can significantly enhance the resistance to P. aeruginosa infection in granulocytopenic mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-13655060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-162811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-2933465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-351618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-3921618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-403841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-4145387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-4151107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-4213977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-4394909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-4628214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-5216294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6174622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6174672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6206190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6404816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6407998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6424466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6429246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6751183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6787121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6799548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2426306-6976357
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2426306-Agranulocytosis,
pubmed-meshheading:2426306-Animals,
pubmed-meshheading:2426306-Antigens, Bacterial,
pubmed-meshheading:2426306-B-Lymphocytes,
pubmed-meshheading:2426306-Epitopes,
pubmed-meshheading:2426306-Female,
pubmed-meshheading:2426306-Immunity, Innate,
pubmed-meshheading:2426306-Immunization, Passive,
pubmed-meshheading:2426306-Mice,
pubmed-meshheading:2426306-Mice, Inbred BALB C,
pubmed-meshheading:2426306-Mice, Inbred C3H,
pubmed-meshheading:2426306-Pseudomonas Infections,
pubmed-meshheading:2426306-Pseudomonas aeruginosa,
pubmed-meshheading:2426306-Species Specificity,
pubmed-meshheading:2426306-T-Lymphocytes
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pubmed:year |
1986
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pubmed:articleTitle |
T lymphocyte-mediated protection against Pseudomonas aeruginosa infection in granulocytopenic mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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